Assay Detail
Binding
CHEMBL1108787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: optimization of human microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 9.13 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091714 | — | — | 1 | 10.00 |
| CHEMBL1091358 | — | — | 1 | 9.85 |
| CHEMBL1091596 | — | — | 1 | 9.74 |
| CHEMBL1092389 | — | — | 1 | 9.60 |
| CHEMBL1092398 | — | — | 1 | 9.59 |
| CHEMBL1091357 | — | — | 1 | 9.47 |
| CHEMBL1091360 | — | — | 1 | 9.40 |
| CHEMBL1091713 | — | — | 1 | 9.38 |
| CHEMBL1091356 | — | — | 1 | 9.34 |
| CHEMBL1091350 | — | — | 1 | 9.28 |
| CHEMBL1091351 | — | — | 1 | 9.27 |
| CHEMBL1091354 | — | — | 1 | 9.25 |
| CHEMBL1091352 | — | — | 1 | 9.25 |
| CHEMBL1092391 | — | — | 1 | 9.24 |
| CHEMBL1092390 | — | — | 1 | 9.24 |
| CHEMBL1091349 | — | — | 1 | 9.15 |
| CHEMBL1091359 | — | — | 1 | 9.15 |
| CHEMBL1091344 | — | — | 1 | 9.15 |
| CHEMBL1092397 | — | — | 1 | 9.10 |
| CHEMBL1091355 | — | — | 1 | 9.09 |
| CHEMBL1091353 | — | — | 1 | 9.06 |
| CHEMBL1092396 | — | — | 1 | 9.05 |
| CHEMBL1092394 | — | — | 1 | 9.05 |
| CHEMBL1091712 | — | — | 1 | 9.05 |
| CHEMBL1088973 | — | — | 1 | 9.00 |
| CHEMBL1092392 | — | — | 1 | 9.00 |
| CHEMBL1092393 | — | — | 1 | 8.96 |
| CHEMBL1091348 | — | — | 1 | 8.92 |
| CHEMBL1076864 | — | — | 1 | 8.92 |
| CHEMBL1091711 | — | — | 1 | 8.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091714 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1091358 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL1091596 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1092389 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1092398 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL1091357 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL1091360 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1091713 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL1091356 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL1091350 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL1091351 | — | IC50 | = | 0.535 | nM | 9.27 |
| CHEMBL1091354 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1091352 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1092391 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1092390 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1091359 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1091349 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1091344 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1092397 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1091355 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1091353 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL1092396 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1092394 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL1091712 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1092392 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1088973 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1092393 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1091348 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1076864 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1091711 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL1092395 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1091715 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1091345 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1091346 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1091347 | — | IC50 | = | 8.8 | nM | 8.06 |