Assay Detail
Functional
CHEMBL1109111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by alamar blue assay
7
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.79 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 5.52 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | — | 3 | 4.51 |
| CHEMBL397829 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319144 | MINODRONIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1099309 | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | IC50 | > | 800000.0 | nM | - |
| CHEMBL397829 | — | IC50 | = | 2800000.0 | nM | - |
| CHEMBL397829 | — | IC50 | - | — | - | |
| CHEMBL397829 | — | IC50 | - | — | - |