Assay Detail
Binding
CHEMBL1109181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chemiluminescence assay
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear factor NF-kappa-B p105 subunit (CHEMBL3251) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.38 | 7.12 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 7.12 |
| CHEMBL1099162 | ARTOBILOXANTHONE | — | 1 | 5.64 |
| CHEMBL109860 | — | — | 1 | - |
| CHEMBL516519 | CYCLOARTOBILOXANTHONE | — | 1 | - |
| CHEMBL1096733 | ARTONIN O | — | 1 | - |
| CHEMBL1096732 | ARTORISTILBENE | — | 1 | - |
| CHEMBL1096731 | CYCLORIGIDOL | — | 1 | - |
| CHEMBL1096730 | ARTORIGIDIN C | — | 1 | - |
| CHEMBL1094757 | ARTORIGIDIN B | — | 1 | - |
| CHEMBL1094756 | ARTORIGIDIN A | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL1097723 | ARTONIN G | — | 1 | - |
| CHEMBL1096045 | ARTONIN K | — | 1 | - |
| CHEMBL1094755 | ARTONIN N | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1099162 | ARTOBILOXANTHONE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL109860 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL516519 | CYCLOARTOBILOXANTHONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096733 | ARTONIN O | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096732 | ARTORISTILBENE | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096731 | CYCLORIGIDOL | IC50 | > | 10000.0 | nM | - |
| CHEMBL1096730 | ARTORIGIDIN C | IC50 | - | — | - | |
| CHEMBL1094757 | ARTORIGIDIN B | IC50 | - | — | - | |
| CHEMBL1094756 | ARTORIGIDIN A | IC50 | > | 10000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | Activity | - | — | - | |
| CHEMBL169 | URSOLIC ACID | Activity | - | — | - | |
| CHEMBL1097723 | ARTONIN G | Activity | - | — | - | |
| CHEMBL1096045 | ARTONIN K | Activity | - | — | - | |
| CHEMBL1094755 | ARTONIN N | Activity | - | — | - |