Assay Detail
Binding
CHEMBL1109341
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Inhibition of Trypanosoma cruzi cruzain after 5 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.07 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91704 | K-777 | 2.0 | 1 | 8.40 |
| CHEMBL1079162 | — | — | 1 | 7.30 |
| CHEMBL1078779 | — | — | 1 | 6.00 |
| CHEMBL1079067 | — | — | 1 | 6.00 |
| CHEMBL1078778 | — | — | 1 | 5.70 |
| CHEMBL1078855 | — | — | 1 | 5.70 |
| CHEMBL1078981 | — | — | 1 | 5.30 |
| CHEMBL1079068 | — | — | 1 | 5.22 |
| CHEMBL1078675 | — | — | 1 | 5.00 |
| CHEMBL1079105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91704 | K-777 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1079162 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1078779 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1079067 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1078778 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1078855 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1078981 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1079068 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1078675 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1079105 | — | IC50 | > | 100000.0 | nM | - |