Assay Detail
Binding
CHEMBL1109728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at LXRalpha ligand binding domain-mediated transcriptional activity in african green monkey CV1 cells co-transfected with Gal4-SRC1 by luciferase reporter assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.28 | 8.20 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093554 | — | — | 1 | 8.20 |
| CHEMBL1091034 | — | — | 1 | 8.00 |
| CHEMBL1091976 | — | — | 1 | 7.90 |
| CHEMBL62136 | T091317 | — | 1 | 7.20 |
| CHEMBL1093523 | — | — | 1 | 7.10 |
| CHEMBL1092952 | — | — | 1 | 7.10 |
| CHEMBL1093840 | — | — | 1 | 7.00 |
| CHEMBL1093828 | — | — | 1 | 6.90 |
| CHEMBL59030 | — | — | 1 | 6.10 |
| CHEMBL1093266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093554 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL1091034 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1091976 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL62136 | T091317 | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1093523 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1092952 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1093840 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1093828 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL59030 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL1093266 | — | pEC50 | - | — | - |