Assay Detail
Binding
CHEMBL1109765
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Binding affinity to OX1 receptor by radioligand displacement assay
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.98 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093725 | — | — | 1 | 9.40 |
| CHEMBL1091110 | — | — | 3 | 9.15 |
| CHEMBL1089406 | — | — | 1 | 9.00 |
| CHEMBL469146 | — | — | 1 | 8.92 |
| CHEMBL1091111 | — | — | 1 | 7.92 |
| CHEMBL1091112 | — | — | 1 | 6.06 |
| CHEMBL1093724 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093725 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1091110 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1089406 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL469146 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1091110 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1091111 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1091110 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1091112 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL1093724 | — | Ki | = | 1700.0 | nM | 5.77 |