Assay Detail
Binding
CHEMBL1109766
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Binding affinity to OX2 receptor by radioligand displacement assay
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.05 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089406 | — | — | 1 | 9.70 |
| CHEMBL469146 | — | — | 1 | 9.22 |
| CHEMBL1093725 | — | — | 1 | 9.22 |
| CHEMBL1091110 | — | — | 3 | 9.05 |
| CHEMBL1091111 | — | — | 1 | 7.96 |
| CHEMBL1091112 | — | — | 1 | 6.58 |
| CHEMBL1093724 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089406 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL469146 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1093725 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1091110 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1091110 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1091111 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1091110 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL1091112 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL1093724 | — | Ki | = | 3500.0 | nM | 5.46 |