Assay Detail
Functional
CHEMBL1109871
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Antiproliferative activity against human Caco-2 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.25 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089823 | — | — | 1 | 5.70 |
| CHEMBL1090115 | — | — | 1 | 5.68 |
| CHEMBL1090478 | — | — | 1 | 5.55 |
| CHEMBL1090153 | — | — | 1 | 5.33 |
| CHEMBL1092189 | — | — | 1 | 5.33 |
| CHEMBL1089653 | — | — | 1 | 5.14 |
| CHEMBL1093445 | — | — | 1 | 5.12 |
| CHEMBL1088835 | — | — | 1 | 5.05 |
| CHEMBL1090505 | — | — | 1 | 5.05 |
| CHEMBL1091855 | — | — | 1 | 5.03 |
| CHEMBL1093448 | — | — | 1 | 5.00 |
| CHEMBL1093449 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089823 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1090115 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1090478 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1090153 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1092189 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1089653 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1093445 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1088835 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1090505 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1091855 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1093448 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1093449 | — | IC50 | = | 10000.0 | nM | 5.00 |