Assay Detail

CHEMBL1109920

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ADMET

Cytotoxicity against HUVEC

ChEMBL ↗

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Target

HUVEC (CHEMBL613979) ↗

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Primary target HUVEC

CHEMBL613979

Anchored from Assay target.

Protein identity HUVEC

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	HUVEC
Confidence	1 — Organism
Curated By	Autocuration

Target

HUVEC (CHEMBL613979) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.

Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P.
Bioorg Med Chem (2010) 18 : 2566 -2574
PubMed 20303767 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.43	6.91

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL331627	GLIOTOXIN	—	1	6.91
CHEMBL1088981	BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN	—	1	5.95

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL331627	GLIOTOXIN	IC50	=	123.0	nM	6.91
CHEMBL1088981	BIS(DETHIO)BIS(METHYLTHIO)GLIOTOXIN	IC50	=	1120.0	nM	5.95