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Assay Detail

CHEMBL1110052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sheep brain dynamin 1 by malachite green GTPase assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.
Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.
J Med Chem (2010) 53 : 4094 -4102
PubMed 20426422 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.03 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1094197 1 6.58
CHEMBL1094850 1 6.48
CHEMBL1098764 1 6.35
CHEMBL67535 1 5.77
CHEMBL1095555 1 5.50
CHEMBL1095483 1 5.37
CHEMBL1094214 1 5.22
CHEMBL1094224 1 5.19
CHEMBL1095866 1 4.77
CHEMBL1096801 1 4.76
CHEMBL1097112 1 4.72
CHEMBL1098763 1 4.44
CHEMBL1096133 1 4.44
CHEMBL1094223 1 4.36
CHEMBL1096145 1 4.29
CHEMBL1095512 1 4.16
CHEMBL1099145 1 4.09
CHEMBL1094849 1 4.00
CHEMBL1094694 1 -
CHEMBL1097111 1 -
CHEMBL1094841 1 -
CHEMBL1097502 1 -
CHEMBL1094232 1 -
CHEMBL1096144 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1094197 IC50 = 260.0 nM 6.58
CHEMBL1094850 IC50 = 330.0 nM 6.48
CHEMBL1098764 IC50 = 450.0 nM 6.35
CHEMBL67535 IC50 = 1700.0 nM 5.77
CHEMBL1095555 IC50 = 3200.0 nM 5.50
CHEMBL1095483 IC50 = 4300.0 nM 5.37
CHEMBL1094214 IC50 = 6000.0 nM 5.22
CHEMBL1094224 IC50 = 6400.0 nM 5.19
CHEMBL1095866 IC50 = 17000.0 nM 4.77
CHEMBL1096801 IC50 = 17300.0 nM 4.76
CHEMBL1097112 IC50 = 19000.0 nM 4.72
CHEMBL1098763 IC50 = 36600.0 nM 4.44
CHEMBL1096133 IC50 = 36000.0 nM 4.44
CHEMBL1094223 IC50 = 44000.0 nM 4.36
CHEMBL1096145 IC50 = 51000.0 nM 4.29
CHEMBL1095512 IC50 = 70000.0 nM 4.16
CHEMBL1099145 IC50 = 82000.0 nM 4.09
CHEMBL1094849 IC50 = 100000.0 nM 4.00
CHEMBL1094694 IC50 > 300000.0 nM -
CHEMBL1097111 IC50 > 300000.0 nM -
CHEMBL1094841 IC50 > 300000.0 nM -
CHEMBL1097502 IC50 > 300000.0 nM -
CHEMBL1094232 IC50 > 300000.0 nM -
CHEMBL1096144 IC50 = 146000.0 nM -