Assay Detail
Binding
CHEMBL1110059
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Binding affinity to human CXCR4 expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096504 | — | — | 1 | 8.47 |
| CHEMBL1094864 | — | — | 1 | 7.80 |
| CHEMBL1088913 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096504 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1094864 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1088913 | — | IC50 | = | 36.0 | nM | 7.44 |