Assay Detail
Binding
CHEMBL1110561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type Bcr-Abl
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Selectively nonselective kinase inhibition: striking the right balance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.41 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.10 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 8.96 |
| CHEMBL1077317 | — | — | 1 | 8.10 |
| CHEMBL1081312 | — | — | 1 | 7.75 |
| CHEMBL1080580 | — | — | 1 | 5.57 |
| CHEMBL1079113 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL941 | IMATINIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1077317 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1081312 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1080580 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1079113 | — | IC50 | = | 11000.0 | nM | 4.96 |