Assay Detail
Functional
CHEMBL1110629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.45 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | -1.0 | 1 | 10.92 |
| CHEMBL1093686 | — | — | 1 | 10.74 |
| CHEMBL225155 | — | — | 1 | 10.57 |
| CHEMBL1091103 | — | — | 2 | 10.11 |
| CHEMBL1089004 | — | — | 1 | 10.06 |
| CHEMBL1090758 | — | — | 1 | 7.87 |
| CHEMBL1089005 | — | — | 1 | 7.71 |
| CHEMBL190006 | — | — | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | EC50 | = | 0.012 | nM | 10.92 |
| CHEMBL1093686 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL225155 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL1091103 | — | EC50 | = | 0.077 | nM | 10.11 |
| CHEMBL1089004 | — | EC50 | = | 0.088 | nM | 10.06 |
| CHEMBL1091103 | — | EC50 | = | 0.344 | nM | 9.46 |
| CHEMBL1090758 | — | EC50 | = | 13.65 | nM | 7.87 |
| CHEMBL1089005 | — | EC50 | = | 19.72 | nM | 7.71 |
| CHEMBL190006 | — | EC50 | = | 23.25 | nM | 7.63 |