Assay Detail

CHEMBL1110906

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human MKN45 cells after 24 hrs by MTT assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

MKN-45 (CHEMBL614354) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

MKN-45 (CHEMBL614354) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MKN-45

CHEMBL614354

Anchored from Assay target.

Protein identity MKN-45

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MKN-45
Confidence	1 — Organism
Curated By	Autocuration

Target

MKN-45 (CHEMBL614354) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis.

Park SY, Choi H, Hwang H, Kang H, Rho JR.
J Nat Prod (2010) 73 : 734 -737
PubMed 20232859 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.52	6.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1098258	GUKULENIN A	—	1	6.89
CHEMBL1098259	GUKULENIN B	—	1	6.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1098258	GUKULENIN A	IC50	=	130.0	nM	6.89
CHEMBL1098259	GUKULENIN B	IC50	=	720.0	nM	6.14