Assay Detail
Binding
CHEMBL1111192
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Inhibition of human recombinant MAOB
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.63 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080449 | — | — | 1 | 5.56 |
| CHEMBL1080705 | — | — | 1 | 5.14 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.12 |
| CHEMBL1081382 | — | — | 1 | 4.89 |
| CHEMBL1080446 | — | — | 1 | 4.79 |
| CHEMBL1080706 | — | — | 1 | 4.74 |
| CHEMBL326294 | ISATIN | — | 1 | 4.73 |
| CHEMBL1080707 | — | — | 1 | 4.63 |
| CHEMBL1076153 | — | — | 1 | 4.53 |
| CHEMBL1080196 | — | — | 1 | 4.49 |
| CHEMBL489743 | — | — | 1 | 4.48 |
| CHEMBL1079383 | — | — | 1 | 4.48 |
| CHEMBL1080035 | — | — | 1 | 4.48 |
| CHEMBL1080447 | — | — | 1 | 4.41 |
| CHEMBL508817 | — | — | 1 | 4.32 |
| CHEMBL1080448 | — | — | 1 | 4.26 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 4.21 |
| CHEMBL1081550 | — | — | 1 | 4.16 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080449 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL1080705 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL1081382 | — | IC50 | = | 12840.0 | nM | 4.89 |
| CHEMBL1080446 | — | IC50 | = | 16330.0 | nM | 4.79 |
| CHEMBL1080706 | — | IC50 | = | 18260.0 | nM | 4.74 |
| CHEMBL326294 | ISATIN | IC50 | = | 18750.0 | nM | 4.73 |
| CHEMBL1080707 | — | IC50 | = | 23210.0 | nM | 4.63 |
| CHEMBL1076153 | — | IC50 | = | 29380.0 | nM | 4.53 |
| CHEMBL1080196 | — | IC50 | = | 32480.0 | nM | 4.49 |
| CHEMBL489743 | — | IC50 | = | 32810.0 | nM | 4.48 |
| CHEMBL1079383 | — | IC50 | = | 33260.0 | nM | 4.48 |
| CHEMBL1080035 | — | IC50 | = | 33290.0 | nM | 4.48 |
| CHEMBL1080447 | — | IC50 | = | 39370.0 | nM | 4.41 |
| CHEMBL508817 | — | IC50 | = | 48310.0 | nM | 4.32 |
| CHEMBL1080448 | — | IC50 | = | 54510.0 | nM | 4.26 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 61350.0 | nM | 4.21 |
| CHEMBL1081550 | — | IC50 | = | 69380.0 | nM | 4.16 |
| CHEMBL972 | SELEGILINE | IC50 | = | 19600.0 | nM | - |