Assay Detail
Binding
CHEMBL1111478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selectively nonselective kinase inhibition: striking the right balance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447328 | — | — | 1 | 8.00 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 7.92 |
| CHEMBL521642 | — | — | 1 | 7.89 |
| CHEMBL182101 | — | — | 1 | 6.80 |
| CHEMBL258844 | — | — | 1 | 6.68 |
| CHEMBL493911 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447328 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL521642 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL182101 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL258844 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL493911 | — | IC50 | = | 1000.0 | nM | 6.00 |