Assay Detail

CHEMBL1111496

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of HDAC

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Selectively nonselective kinase inhibition: striking the right balance.

Morphy R.
J Med Chem (2010) 53 : 1413 -1437
PubMed 20166671 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.73	8.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL598797	CUDC-101	1.0	1	8.36
CHEMBL1080580	—	—	1	7.10
CHEMBL941	IMATINIB	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL598797	CUDC-101	IC50	=	4.4	nM	8.36
CHEMBL1080580	—	IC50	=	80.0	nM	7.10
CHEMBL941	IMATINIB	IC50	>	100.0	nM	-