Assay Detail
Binding
CHEMBL1111552
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Inhibition of PARP1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of tricyclic derivatives containing a non-aromatic amide as inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.27 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089713 | — | — | 1 | 7.89 |
| CHEMBL1092777 | — | — | 1 | 7.60 |
| CHEMBL1093295 | — | — | 1 | 7.55 |
| CHEMBL1092144 | — | — | 1 | 7.54 |
| CHEMBL1090020 | — | — | 1 | 7.42 |
| CHEMBL1092776 | — | — | 1 | 7.41 |
| CHEMBL1092145 | — | — | 1 | 7.40 |
| CHEMBL190434 | — | — | 1 | 7.40 |
| CHEMBL1094039 | — | — | 1 | 7.38 |
| CHEMBL1091454 | — | — | 1 | 7.35 |
| CHEMBL1090019 | — | — | 1 | 7.28 |
| CHEMBL1092778 | — | — | 1 | 7.25 |
| CHEMBL1092143 | — | — | 1 | 7.15 |
| CHEMBL1093610 | — | — | 1 | 7.10 |
| CHEMBL1091710 | — | — | 1 | 7.00 |
| CHEMBL1089332 | — | — | 1 | 6.76 |
| CHEMBL1090018 | — | — | 1 | 6.16 |
| CHEMBL1089020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089713 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1092777 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1093295 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1092144 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1090020 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1092776 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1092145 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL190434 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1094039 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1091454 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1090019 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1092778 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1092143 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1093610 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1091710 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1089332 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL1090018 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL1089020 | — | IC50 | > | 10000.0 | nM | - |