Assay Detail
Functional
CHEMBL1111629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P1 receptor expressed in human Chem1 cells assessed as intracellular calcium mobilization
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Chem1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.79 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 9.46 |
| CHEMBL1089557 | — | — | 1 | 9.28 |
| CHEMBL1092577 | — | — | 1 | 9.21 |
| CHEMBL1096210 | — | — | 1 | 9.19 |
| CHEMBL1096211 | — | — | 1 | 9.09 |
| CHEMBL1090819 | — | — | 1 | 9.08 |
| CHEMBL1092272 | — | — | 1 | 8.96 |
| CHEMBL1095889 | — | — | 1 | 8.96 |
| CHEMBL1089558 | — | — | 1 | 8.92 |
| CHEMBL1091630 | — | — | 1 | 8.89 |
| CHEMBL1090223 | — | — | 1 | 8.80 |
| CHEMBL1092284 | — | — | 1 | 8.74 |
| CHEMBL1089809 | — | — | 1 | 8.70 |
| CHEMBL1092285 | — | — | 1 | 8.68 |
| CHEMBL1089475 | — | — | 1 | 8.52 |
| CHEMBL1089564 | — | — | 1 | 8.51 |
| CHEMBL1092286 | — | — | 1 | 8.44 |
| CHEMBL1089810 | — | — | 1 | 8.38 |
| CHEMBL1093574 | — | — | 1 | 8.33 |
| CHEMBL1093573 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1089557 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL1092577 | — | EC50 | = | 0.62 | nM | 9.21 |
| CHEMBL1096210 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL1096211 | — | EC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1090819 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL1092272 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1095889 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1089558 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1091630 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1090223 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1092284 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1089809 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1092285 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1089475 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1089564 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1092286 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1089810 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1093574 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1093573 | — | EC50 | = | 21.0 | nM | 7.68 |