Assay Detail
Binding
CHEMBL1111769
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Inhibition of Varicella zoster virus thymidine kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.29 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091988 | — | — | 1 | 5.77 |
| CHEMBL1090132 | — | — | 1 | 5.60 |
| CHEMBL1090868 | — | — | 1 | 5.57 |
| CHEMBL1090134 | — | — | 1 | 5.51 |
| CHEMBL1091719 | — | — | 1 | 5.51 |
| CHEMBL1089867 | — | — | 1 | 5.48 |
| CHEMBL1091931 | — | — | 1 | 5.43 |
| CHEMBL1089805 | — | — | 1 | 5.37 |
| CHEMBL1090133 | — | — | 1 | 5.19 |
| CHEMBL1092729 | — | — | 1 | 4.82 |
| CHEMBL1090869 | — | — | 1 | 4.72 |
| CHEMBL1091210 | — | — | 1 | 4.52 |
| CHEMBL1092055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091988 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1090132 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1090868 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1090134 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1091719 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1089867 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1091931 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1089805 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1090133 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1092729 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1090869 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1091210 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1092055 | — | IC50 | > | 500000.0 | nM | - |