Assay Detail
Binding
CHEMBL1111776
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Displacement of [3H]vesamicol from VAChT in Torpedo californica cholinergic synaptic vesicles
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vesicular acetylcholine transporter (CHEMBL3313) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.94 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 10.26 |
| CHEMBL1204042 | — | — | 1 | 9.39 |
| CHEMBL1204040 | — | — | 1 | 9.28 |
| CHEMBL1204037 | — | — | 1 | 9.27 |
| CHEMBL1204038 | — | — | 1 | 9.18 |
| CHEMBL1204029 | — | — | 1 | 8.86 |
| CHEMBL1204027 | — | — | 1 | 8.79 |
| CHEMBL1204028 | — | — | 1 | 8.74 |
| CHEMBL20730 | VESAMICOL | — | 1 | 8.70 |
| CHEMBL1204049 | — | — | 1 | 8.68 |
| CHEMBL1204047 | — | — | 1 | 8.68 |
| CHEMBL1204048 | — | — | 1 | 8.62 |
| CHEMBL1204039 | — | — | 1 | 8.62 |
| CHEMBL1204041 | — | — | 1 | 8.31 |
| CHEMBL1204036 | — | — | 1 | 8.30 |
| CHEMBL1204043 | — | — | 1 | 8.12 |
| CHEMBL1204045 | — | — | 1 | 7.53 |
| CHEMBL1204046 | — | — | 1 | 7.51 |
| CHEMBL1204034 | — | — | 1 | 7.33 |
| CHEMBL1092295 | — | — | 1 | 7.30 |
| CHEMBL1204032 | — | — | 1 | 7.29 |
| CHEMBL1204050 | — | — | 1 | 7.16 |
| CHEMBL1204026 | — | — | 1 | 7.16 |
| CHEMBL1204051 | — | — | 1 | 7.05 |
| CHEMBL1204044 | — | — | 1 | 6.87 |
| CHEMBL1204031 | — | — | 1 | 6.37 |
| CHEMBL1204052 | — | — | 1 | 6.35 |
| CHEMBL1204035 | — | — | 1 | 6.25 |
| CHEMBL1204030 | — | — | 1 | 6.19 |
| CHEMBL1204033 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL1204042 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1204040 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL1204037 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL1204038 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL1204029 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL1204027 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL1204028 | — | Ki | = | 1.83 | nM | 8.74 |
| CHEMBL20730 | VESAMICOL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1204049 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL1204047 | — | Ki | = | 2.07 | nM | 8.68 |
| CHEMBL1204048 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1204039 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1204041 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL1204036 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1204043 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1204045 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL1204046 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1204034 | — | Ki | = | 46.8 | nM | 7.33 |
| CHEMBL1092295 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1204032 | — | Ki | = | 51.4 | nM | 7.29 |
| CHEMBL1204050 | — | Ki | = | 68.5 | nM | 7.16 |
| CHEMBL1204026 | — | Ki | = | 68.5 | nM | 7.16 |
| CHEMBL1204051 | — | Ki | = | 89.5 | nM | 7.05 |
| CHEMBL1204044 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL1204031 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL1204052 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL1204035 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL1204030 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL1204033 | — | Ki | = | 763.0 | nM | 6.12 |