Assay Detail
Binding
CHEMBL1111806
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Binding affinity to p38beta
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.50 | 7.82 |
| Ki | 1 | 7.60 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 7.82 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 7.77 |
| CHEMBL1088752 | LOSMAPIMOD | 3.0 | 1 | 7.60 |
| CHEMBL1090089 | PAMAPIMOD | 2.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514201 | TALMAPIMOD | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL1090090 | VX-702 | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL1088752 | LOSMAPIMOD | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1090089 | PAMAPIMOD | Kd | = | 120.0 | nM | 6.92 |