Assay Detail
Functional
CHEMBL1111883
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Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 8425 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 6 | - | - |
| IC50 | 6 | 7.63 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096247 | — | — | 2 | 8.10 |
| CHEMBL1096901 | — | — | 2 | 8.06 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 7.59 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 2 | 7.58 |
| CHEMBL272416 | — | — | 2 | 7.54 |
| CHEMBL170 | QUININE | 4.0 | 2 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096247 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1096901 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL272416 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL170 | QUININE | IC50 | = | 130.3 | nM | 6.88 |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 59.2 | nM | - |
| CHEMBL170 | QUININE | IC90 | = | 389.9 | nM | - |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC90 | = | 41.4 | nM | - |
| CHEMBL272416 | — | IC90 | = | 59.4 | nM | - |
| CHEMBL1096901 | — | IC90 | = | 16.9 | nM | - |
| CHEMBL1096247 | — | IC90 | = | 12.8 | nM | - |