Assay Detail
Binding
CHEMBL1112302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]noradrenaline from human NET receptor expressed in HEK293 cells by scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.30 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079263 | — | — | 1 | 8.00 |
| CHEMBL1079264 | — | — | 1 | 7.96 |
| CHEMBL1080968 | — | — | 1 | 7.96 |
| CHEMBL1080790 | — | — | 1 | 7.89 |
| CHEMBL1080787 | — | — | 1 | 7.68 |
| CHEMBL1080789 | — | — | 1 | 7.62 |
| CHEMBL1078074 | — | — | 1 | 7.58 |
| CHEMBL1078162 | — | — | 1 | 7.54 |
| CHEMBL1080069 | — | — | 1 | 7.44 |
| CHEMBL1080969 | — | — | 1 | 7.43 |
| CHEMBL1079265 | — | — | 1 | 7.43 |
| CHEMBL1078741 | — | — | 1 | 7.37 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 7.35 |
| CHEMBL1078742 | — | — | 1 | 7.30 |
| CHEMBL476954 | — | — | 1 | 7.28 |
| CHEMBL1078169 | — | — | 1 | 7.19 |
| CHEMBL1078164 | — | — | 1 | 7.17 |
| CHEMBL1078163 | — | — | 1 | 7.16 |
| CHEMBL1080788 | — | — | 1 | 7.02 |
| CHEMBL1077638 | — | — | 1 | 6.99 |
| CHEMBL1078743 | — | — | 1 | 6.87 |
| CHEMBL1078073 | — | — | 1 | 6.86 |
| CHEMBL1078170 | — | — | 1 | 6.77 |
| CHEMBL1077647 | — | — | 1 | 6.70 |
| CHEMBL1078312 | — | — | 1 | 6.66 |
| CHEMBL1078076 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079263 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1079264 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1080968 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1080790 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1080787 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1080789 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1078074 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1078162 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1080069 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1080969 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1079265 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1078741 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1175 | DULOXETINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL1078742 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL476954 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL1078169 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1078164 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL1078163 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL1080788 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1077638 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL1078743 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL1078073 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL1078170 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL1077647 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL1078312 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL1078076 | — | Ki | = | 263.0 | nM | 6.58 |