Assay Detail
Binding
CHEMBL1112366
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Inhibition of chymotrypsin like activity of yeast 20S proteasome beta 5 subunit after 30 mins by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.39 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 8.72 |
| CHEMBL1077383 | SALINOSPORAMIDE X7 | — | 1 | 8.66 |
| CHEMBL1081673 | — | — | 1 | 8.03 |
| CHEMBL192046 | — | — | 1 | 7.56 |
| CHEMBL1081854 | SALINOSPORAMIDE X3 | — | 1 | 7.03 |
| CHEMBL561240 | ANTIPROTEALIDE | — | 1 | 7.00 |
| CHEMBL1080762 | SALINOSPORAMIDE X6 | — | 1 | 6.88 |
| CHEMBL1077389 | SALINOSPORAMIDE X5 | — | 1 | 6.61 |
| CHEMBL1080230 | SALINOSPORAMIDE X4 | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1077383 | SALINOSPORAMIDE X7 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1081673 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL192046 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL1081854 | SALINOSPORAMIDE X3 | IC50 | = | 93.4 | nM | 7.03 |
| CHEMBL561240 | ANTIPROTEALIDE | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1080762 | SALINOSPORAMIDE X6 | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1077389 | SALINOSPORAMIDE X5 | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL1080230 | SALINOSPORAMIDE X4 | IC50 | = | 1029.0 | nM | 5.99 |