Assay Detail
Functional
CHEMBL1112752
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Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 6 | - | - |
| IC50 | 6 | 6.79 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096247 | — | — | 2 | 7.24 |
| CHEMBL1096901 | — | — | 2 | 7.06 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 2 | 7.04 |
| CHEMBL272416 | — | — | 2 | 6.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.31 |
| CHEMBL170 | QUININE | 4.0 | 2 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096247 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL1096901 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL272416 | — | IC50 | = | 129.7 | nM | 6.89 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 493.2 | nM | 6.31 |
| CHEMBL170 | QUININE | IC50 | = | 619.4 | nM | 6.21 |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 912.0 | nM | - |
| CHEMBL170 | QUININE | IC90 | = | 1510.1 | nM | - |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC90 | = | 143.6 | nM | - |
| CHEMBL272416 | — | IC90 | = | 285.1 | nM | - |
| CHEMBL1096901 | — | IC90 | = | 247.2 | nM | - |
| CHEMBL1096247 | — | IC90 | = | 104.7 | nM | - |