Assay Detail
Binding
CHEMBL1112964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of labeled MK-499 from human ERG in HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.68 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94417 | — | — | 1 | 6.06 |
| CHEMBL219804 | — | — | 1 | 5.29 |
| CHEMBL1098524 | — | — | 1 | - |
| CHEMBL1098554 | — | — | 1 | - |
| CHEMBL1096192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94417 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL219804 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL1098524 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL1098554 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL1096192 | — | Ki | > | 20000.0 | nM | - |