Assay Detail
Binding
CHEMBL1112965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of PXR
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.48 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098524 | — | — | 1 | 5.48 |
| CHEMBL1098525 | — | — | 1 | - |
| CHEMBL1098797 | — | — | 1 | - |
| CHEMBL1096830 | — | — | 1 | - |
| CHEMBL1098546 | — | — | 1 | - |
| CHEMBL1098822 | — | — | 1 | - |
| CHEMBL1098551 | — | — | 1 | - |
| CHEMBL1098552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098524 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1098525 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1098797 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1096830 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1098546 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1098822 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1098551 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1098552 | — | EC50 | > | 30000.0 | nM | - |