Assay Detail
Functional
CHEMBL1113508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GAL4-tagged PPARalpha chimeric receptor expressed in HEK cells by transactivation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.09 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410478 | — | — | 1 | 8.00 |
| CHEMBL1089633 | — | — | 1 | 7.92 |
| CHEMBL1089634 | — | — | 1 | 5.87 |
| CHEMBL1089632 | — | — | 1 | 5.84 |
| CHEMBL1089177 | — | — | 1 | 5.05 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 4.98 |
| CHEMBL1090859 | — | — | 1 | 4.95 |
| CHEMBL1090860 | — | — | 1 | - |
| CHEMBL1090861 | — | — | 1 | - |
| CHEMBL1090557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410478 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1089633 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1089634 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1089632 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1089177 | — | EC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 10580.0 | nM | 4.98 |
| CHEMBL1090859 | — | EC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL1090860 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1090861 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1090557 | — | EC50 | > | 100000.0 | nM | - |