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Assay Detail

CHEMBL1113541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]T0901317 from human LXRbeta ligand binding domain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Hu B, Unwalla RJ, Goljer I, Jetter JW, Quinet EM, Berrodin TJ, Basso MD, Feingold IB, Nilsson AG, Wilhelmsson A, Evans MJ, Wrobel JE.
J Med Chem (2010) 53 : 3296 -3304
PubMed 20350005 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.08 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1089232 1 7.75
CHEMBL1093499 1 7.47
CHEMBL1093532 1 7.28
CHEMBL602446 1 7.21
CHEMBL1090916 1 7.09
CHEMBL1093260 1 6.88
CHEMBL1093915 1 6.52
CHEMBL1093916 1 6.40
CHEMBL1089900 1 -
CHEMBL1089901 1 -
CHEMBL1093258 1 -
CHEMBL1093259 1 -
CHEMBL1089233 1 -
CHEMBL1089231 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1089232 IC50 = 18.0 nM 7.75
CHEMBL1093499 IC50 = 34.0 nM 7.47
CHEMBL1093532 IC50 = 53.0 nM 7.28
CHEMBL602446 IC50 = 61.0 nM 7.21
CHEMBL1090916 IC50 = 81.0 nM 7.09
CHEMBL1093260 IC50 = 132.0 nM 6.88
CHEMBL1093915 IC50 = 299.0 nM 6.52
CHEMBL1093916 IC50 = 395.0 nM 6.40
CHEMBL1089900 IC50 > 1000.0 nM -
CHEMBL1089901 IC50 > 1000.0 nM -
CHEMBL1093258 IC50 > 1000.0 nM -
CHEMBL1093259 IC50 > 1000.0 nM -
CHEMBL1089233 IC50 > 1000.0 nM -
CHEMBL1089231 IC50 > 1000.0 nM -