Assay Detail
Binding
CHEMBL1114231
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Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.43 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077183 | — | — | 1 | 8.05 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.54 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077183 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 196.0 | nM | 6.71 |