Assay Detail
Binding
CHEMBL1114349
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Inhibition of human recombinant COX2 by enzyme immuno assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.36 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.96 |
| CHEMBL1092135 | — | — | 1 | 5.89 |
| CHEMBL1092137 | — | — | 1 | 5.26 |
| CHEMBL1092136 | — | — | 1 | 5.23 |
| CHEMBL1092138 | — | — | 1 | 5.19 |
| CHEMBL1089958 | — | — | 1 | 5.10 |
| CHEMBL1089959 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1092135 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1092137 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1092136 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1092138 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1089958 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1089959 | — | IC50 | = | 12900.0 | nM | 4.89 |