Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1114459

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IgG binding to soluble human FcRn after 5 hrs by competition ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

IgG receptor FcRn large subunit p51 (CHEMBL5966)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.
McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, Sakorafas P, Mezo AR.
J Med Chem (2010) 53 : 1587 -1596
PubMed 20092334 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.06 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1090633 1 8.80
CHEMBL1090970 1 8.62
CHEMBL1090632 1 8.62
CHEMBL2304309 1 8.59
CHEMBL1090640 1 8.41
CHEMBL1090278 1 8.41
CHEMBL1090968 1 8.38
CHEMBL1090638 1 8.34
CHEMBL1090636 1 8.33
CHEMBL2304310 1 8.32
CHEMBL1090637 1 8.30
CHEMBL1090635 1 8.28
CHEMBL1090639 1 8.25
CHEMBL1090279 1 7.75
CHEMBL1090969 1 7.70
CHEMBL1090280 1 7.30
CHEMBL1089946 1 6.37
CHEMBL1089948 1 6.28
CHEMBL1090276 1 6.24
CHEMBL1089952 1 6.22
CHEMBL1090275 1 6.15
CHEMBL1089949 1 6.00
CHEMBL1090274 1 5.96
CHEMBL1089947 1 5.96
CHEMBL2304308 1 5.72
CHEMBL1090273 1 5.62
CHEMBL1090277 1 5.52
CHEMBL1089950 1 4.66
CHEMBL1089945 1 4.43
CHEMBL1089944 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1090633 IC50 = 1.6 nM 8.80
CHEMBL1090970 IC50 = 2.4 nM 8.62
CHEMBL1090632 IC50 = 2.4 nM 8.62
CHEMBL2304309 IC50 = 2.6 nM 8.59
CHEMBL1090640 IC50 = 3.9 nM 8.41
CHEMBL1090278 IC50 = 3.9 nM 8.41
CHEMBL1090968 IC50 = 4.2 nM 8.38
CHEMBL1090638 IC50 = 4.6 nM 8.34
CHEMBL1090636 IC50 = 4.7 nM 8.33
CHEMBL2304310 IC50 = 4.8 nM 8.32
CHEMBL1090637 IC50 = 5.0 nM 8.30
CHEMBL1090635 IC50 = 5.2 nM 8.28
CHEMBL1090639 IC50 = 5.6 nM 8.25
CHEMBL1090279 IC50 = 18.0 nM 7.75
CHEMBL1090969 IC50 = 20.0 nM 7.70
CHEMBL1090280 IC50 = 50.0 nM 7.30
CHEMBL1089946 IC50 = 430.0 nM 6.37
CHEMBL1089948 IC50 = 520.0 nM 6.28
CHEMBL1090276 IC50 = 580.0 nM 6.24
CHEMBL1089952 IC50 = 600.0 nM 6.22
CHEMBL1090275 IC50 = 710.0 nM 6.15
CHEMBL1089949 IC50 = 1000.0 nM 6.00
CHEMBL1090274 IC50 = 1100.0 nM 5.96
CHEMBL1089947 IC50 = 1100.0 nM 5.96
CHEMBL2304308 IC50 = 1900.0 nM 5.72
CHEMBL1090273 IC50 = 2400.0 nM 5.62
CHEMBL1090277 IC50 = 3000.0 nM 5.52
CHEMBL1089950 IC50 = 22000.0 nM 4.66
CHEMBL1089945 IC50 = 37000.0 nM 4.43
CHEMBL1089944 IC50 = 40000.0 nM 4.40