Assay Detail
Binding
CHEMBL1114461
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Binding affinity to soluble human FcRn at pH 7.4 by surface plasmon resonance assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.96 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089949 | — | — | 1 | 7.13 |
| CHEMBL1089948 | — | — | 1 | 6.77 |
| CHEMBL1089946 | — | — | 1 | 6.58 |
| CHEMBL2304308 | — | — | 1 | 6.03 |
| CHEMBL1089947 | — | — | 1 | 6.02 |
| CHEMBL1089950 | — | — | 1 | 4.75 |
| CHEMBL1089944 | — | — | 1 | 4.43 |
| CHEMBL1089945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089949 | — | Kd | = | 74.0 | nM | 7.13 |
| CHEMBL1089948 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL1089946 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL2304308 | — | Kd | = | 930.0 | nM | 6.03 |
| CHEMBL1089947 | — | Kd | = | 950.0 | nM | 6.02 |
| CHEMBL1089950 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL1089944 | — | Kd | = | 37000.0 | nM | 4.43 |
| CHEMBL1089945 | — | Kd | - | — | - |