Assay Detail
Binding
CHEMBL1114546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of voltage-dependent Ca(+) channel in Wistar rat brain piriform cortex acutely dissociated neurons assessed as inhibition of high voltage activated Ba+ current amplitude at under holding potential of -60 mV by whole cell patch clamp assay
5
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Piriform cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.55 | 4.62 |
| Inhibition | 2 | - | - |
| INH | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090093 | — | — | 2 | 4.62 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 4.47 |
| CHEMBL1093767 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090093 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL744 | RILUZOLE | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL1093767 | — | Inhibition | - | % | - | |
| CHEMBL1090093 | — | Inhibition | - | % | - | |
| CHEMBL1093767 | — | INH | = | 112.9 | uM | - |