Assay Detail
Functional
CHEMBL1115072
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Inhibition of HCV genotype 1b NS5B polymerase deltaC21 mutant
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091279 | — | — | 1 | 8.10 |
| CHEMBL559638 | — | — | 1 | 7.70 |
| CHEMBL549821 | — | — | 1 | 7.41 |
| CHEMBL1092980 | — | — | 1 | 7.12 |
| CHEMBL1090920 | — | — | 1 | 7.12 |
| CHEMBL1095885 | — | — | 1 | 6.89 |
| CHEMBL1091654 | — | — | 1 | 6.80 |
| CHEMBL1091278 | — | — | 1 | 6.70 |
| CHEMBL1091240 | — | — | 1 | 6.42 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 6.09 |
| CHEMBL1091239 | — | — | 1 | 6.08 |
| CHEMBL1091616 | — | — | 1 | 5.96 |
| CHEMBL1093522 | — | — | 1 | 5.70 |
| CHEMBL1092686 | — | — | 1 | 5.62 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.58 |
| CHEMBL1090922 | — | — | 1 | 5.52 |
| CHEMBL1090921 | — | — | 1 | 5.28 |
| CHEMBL1095563 | — | — | 1 | 5.28 |
| CHEMBL1093521 | — | — | 1 | 5.26 |
| CHEMBL1093221 | — | — | 1 | 5.18 |
| CHEMBL1095886 | — | — | 1 | - |
| CHEMBL561162 | — | — | 1 | - |
| CHEMBL1091238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091279 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL559638 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL549821 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1092980 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1090920 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1095885 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1091654 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1091278 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1091240 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1091239 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1091616 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1093522 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1092686 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1090922 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1090921 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1095563 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1093521 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1093221 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1095886 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL561162 | — | IC50 | < | 14.0 | nM | - |
| CHEMBL1091238 | — | IC50 | > | 10000.0 | nM | - |