Assay Detail
Binding
CHEMBL1115073
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Inhibition of HCV genotype 2b NS5B polymerase deltaC21 mutant
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.01 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561162 | — | — | 1 | 7.37 |
| CHEMBL1091279 | — | — | 1 | 6.85 |
| CHEMBL559638 | — | — | 1 | 6.75 |
| CHEMBL549821 | — | — | 1 | 6.68 |
| CHEMBL1093221 | — | — | 1 | 6.40 |
| CHEMBL1091616 | — | — | 1 | 6.31 |
| CHEMBL1091278 | — | — | 1 | 6.17 |
| CHEMBL1091654 | — | — | 1 | 6.14 |
| CHEMBL1092980 | — | — | 1 | 6.14 |
| CHEMBL1090920 | — | — | 1 | 5.89 |
| CHEMBL1095885 | — | — | 1 | 5.70 |
| CHEMBL1090921 | — | — | 1 | 5.64 |
| CHEMBL1090922 | — | — | 1 | 5.30 |
| CHEMBL1092686 | — | — | 1 | 5.28 |
| CHEMBL1091240 | — | — | 1 | 5.28 |
| CHEMBL1095563 | — | — | 1 | 5.11 |
| CHEMBL1093522 | — | — | 1 | 5.09 |
| CHEMBL1093521 | — | — | 1 | - |
| CHEMBL1095886 | — | — | 1 | - |
| CHEMBL1091238 | — | — | 1 | - |
| CHEMBL1091239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561162 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1091279 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL559638 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL549821 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1093221 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1091616 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1091278 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1091654 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1092980 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1090920 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1095885 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1090921 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1090922 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1092686 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1091240 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1095563 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1093522 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1093521 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1095886 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091239 | — | IC50 | > | 5000.0 | nM | - |