Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1115076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus H2B2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Malancona S, Donghi M, Ferrara M, Martin Hernando JI, Pompei M, Pesci S, Ontoria JM, Koch U, Rowley M, Summa V.
Bioorg Med Chem (2010) 18 : 2836 -2848
PubMed 20363140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.10 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL284328 HOMIDIUM BROMIDE 2.0 1 6.22
CHEMBL561162 1 5.77
CHEMBL1091239 1 5.58
CHEMBL1091279 1 5.31
CHEMBL1092980 1 5.18
CHEMBL1090921 1 4.80
CHEMBL1091616 1 4.77
CHEMBL559638 1 4.75
CHEMBL1091654 1 4.70
CHEMBL1091278 1 4.58
CHEMBL549821 1 4.46
CHEMBL1093221 1 -
CHEMBL1091240 1 -
CHEMBL53463 DOXORUBICIN 4.0 1 -
CHEMBL1091238 1 -
CHEMBL1093521 1 -
CHEMBL1095886 1 -
CHEMBL1095885 1 -
CHEMBL1095563 1 -
CHEMBL1093522 1 -
CHEMBL1090920 1 -
CHEMBL1090922 1 -
CHEMBL1092686 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL284328 HOMIDIUM BROMIDE EC50 = 600.0 nM 6.22
CHEMBL561162 EC50 = 1700.0 nM 5.77
CHEMBL1091239 EC50 = 2600.0 nM 5.58
CHEMBL1091279 EC50 = 4900.0 nM 5.31
CHEMBL1092980 EC50 = 6600.0 nM 5.18
CHEMBL1090921 EC50 = 16000.0 nM 4.80
CHEMBL1091616 EC50 = 17000.0 nM 4.77
CHEMBL559638 EC50 = 18000.0 nM 4.75
CHEMBL1091654 EC50 = 20000.0 nM 4.70
CHEMBL1091278 EC50 = 26000.0 nM 4.58
CHEMBL549821 EC50 = 35000.0 nM 4.46
CHEMBL1093221 EC50 < 100000.0 nM -
CHEMBL1091240 EC50 - -
CHEMBL53463 DOXORUBICIN EC50 < 300.0 nM -
CHEMBL1091238 EC50 - -
CHEMBL1093521 EC50 > 100000.0 nM -
CHEMBL1095886 EC50 - -
CHEMBL1095885 EC50 > 100000.0 nM -
CHEMBL1095563 EC50 > 100000.0 nM -
CHEMBL1093522 EC50 > 100000.0 nM -
CHEMBL1090920 EC50 > 25000.0 nM -
CHEMBL1090922 EC50 > 100000.0 nM -
CHEMBL1092686 EC50 > 100000.0 nM -