Assay Detail
Binding
CHEMBL1115348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Flt3 activity in human MV 3:11 cells by phosphotyrosine cell-based ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.77 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210833 | — | — | 1 | 5.54 |
| CHEMBL1093100 | — | — | 1 | 4.40 |
| CHEMBL1093099 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210833 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1093100 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL1093099 | — | IC50 | = | 41200.0 | nM | 4.38 |