Assay Detail
Binding
CHEMBL1115565
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Inhibition of human NET transfected in MDCK-Net6 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-Net6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.84 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 8.47 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.40 |
| CHEMBL1099179 | — | — | 1 | 7.52 |
| CHEMBL1096495 | — | — | 1 | 7.25 |
| CHEMBL1095850 | — | — | 1 | 7.24 |
| CHEMBL1097148 | — | — | 1 | 7.02 |
| CHEMBL1095525 | — | — | 1 | 7.00 |
| CHEMBL1095523 | — | — | 1 | 6.65 |
| CHEMBL1097469 | — | — | 1 | 6.59 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 6.27 |
| CHEMBL1097470 | — | — | 1 | 6.26 |
| CHEMBL1099212 | — | — | 1 | 6.24 |
| CHEMBL1095524 | — | — | 1 | 6.14 |
| CHEMBL1099178 | — | — | 1 | 4.75 |
| CHEMBL1097146 | — | — | 1 | - |
| CHEMBL1097147 | — | — | 1 | - |
| CHEMBL1097660 | — | — | 1 | - |
| CHEMBL1099134 | — | — | 1 | - |
| CHEMBL1098855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1099179 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1096495 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1095850 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1097148 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1095525 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1095523 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1097469 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL637 | VENLAFAXINE | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL1097470 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1099212 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL1095524 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1099178 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1097146 | — | IC50 | - | — | - | |
| CHEMBL1097147 | — | IC50 | - | — | - | |
| CHEMBL1097660 | — | IC50 | - | — | - | |
| CHEMBL1099134 | — | IC50 | - | — | - | |
| CHEMBL1098855 | — | IC50 | - | — | - |