Assay Detail
Binding
CHEMBL1115599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.55 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150315 | — | — | 1 | 4.75 |
| CHEMBL485320 | — | — | 1 | 4.35 |
| CHEMBL1094423 | — | — | 1 | - |
| CHEMBL1096972 | — | — | 1 | - |
| CHEMBL520803 | — | — | 1 | - |
| CHEMBL1097743 | — | — | 1 | - |
| CHEMBL483312 | — | — | 1 | - |
| CHEMBL1096737 | — | — | 1 | - |
| CHEMBL483108 | — | — | 1 | - |
| CHEMBL1096415 | — | — | 1 | - |
| CHEMBL482715 | — | — | 1 | - |
| CHEMBL1096416 | — | — | 1 | - |
| CHEMBL483313 | — | — | 1 | - |
| CHEMBL1097368 | — | — | 1 | - |
| CHEMBL499067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150315 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL485320 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL1094423 | — | IC50 | = | 129400.0 | nM | - |
| CHEMBL1096972 | — | IC50 | = | 142300.0 | nM | - |
| CHEMBL520803 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1097743 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483312 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1096737 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483108 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1096415 | — | IC50 | = | 164300.0 | nM | - |
| CHEMBL482715 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1096416 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483313 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1097368 | — | IC50 | = | 223800.0 | nM | - |
| CHEMBL499067 | — | IC50 | > | 200000.0 | nM | - |