Assay Detail
Binding
CHEMBL1116252
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Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.13 | 8.68 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1099284 | — | — | 2 | 8.68 |
| CHEMBL1095274 | — | — | 1 | 8.24 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1099284 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1095274 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL589390 | LATREPIRDINE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL1099284 | — | Activity | - | — | - |