Assay Detail
Functional
CHEMBL1116601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b infected in human HuH7 cells by replicon assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.99 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078194 | — | — | 1 | 5.62 |
| CHEMBL1080765 | — | — | 1 | 5.58 |
| CHEMBL1079699 | — | — | 1 | 5.47 |
| CHEMBL1078092 | — | — | 1 | 5.44 |
| CHEMBL1079698 | — | — | 1 | 4.80 |
| CHEMBL1079701 | — | — | 1 | 4.58 |
| CHEMBL1080764 | — | — | 1 | 4.50 |
| CHEMBL1078093 | — | — | 1 | 4.50 |
| CHEMBL1079700 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078194 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1080765 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1079699 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1078092 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1079698 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1079701 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1080764 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1078093 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1079700 | — | EC50 | = | 37000.0 | nM | 4.43 |