Assay Detail
Functional
CHEMBL1116602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 2a infected in human HuH7 cells by replicon assay
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.24 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078092 | — | — | 2 | 5.43 |
| CHEMBL1078194 | — | — | 1 | 5.31 |
| CHEMBL1080765 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078092 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1078194 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1080765 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1078092 | — | EC50 | = | 9600.0 | nM | 5.02 |