Assay Detail

CHEMBL1116604

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Functional

Inhibition of HCV2a Cdelta21 NS5B polymerase

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepatitis C virus subtype 2a
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.

Pacini B, Avolio S, Ercolani C, Koch U, Migliaccio G, Narjes F, Pacini L, Tomei L, Harper S.
Bioorg Med Chem Lett (2009) 19 : 6245 -6249
PubMed 19800789 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.68	8.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1078092	—	—	1	8.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1078092	—	IC50	=	2.1	nM	8.68