Assay Detail
Binding
CHEMBL1116836
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Inhibition of HCMV recombinant DNA polymerase expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077295 | — | — | 1 | 8.40 |
| CHEMBL1077294 | — | — | 1 | 8.10 |
| CHEMBL1082562 | — | — | 1 | 7.85 |
| CHEMBL1095037 | — | — | 1 | 7.46 |
| CHEMBL1077292 | — | — | 1 | 7.38 |
| CHEMBL481172 | — | — | 1 | 7.12 |
| CHEMBL1077293 | — | — | 1 | 7.01 |
| CHEMBL1085684 | — | — | 1 | 6.96 |
| CHEMBL1083531 | — | — | 1 | 6.89 |
| CHEMBL1084700 | — | — | 1 | 6.82 |
| CHEMBL1077296 | — | — | 1 | 6.75 |
| CHEMBL1083526 | — | — | 1 | 6.72 |
| CHEMBL1087815 | — | — | 1 | 6.58 |
| CHEMBL1084152 | — | — | 1 | 6.52 |
| CHEMBL1097364 | — | — | 1 | 6.46 |
| CHEMBL195453 | — | — | 1 | 6.40 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.31 |
| CHEMBL1086423 | — | — | 1 | 6.31 |
| CHEMBL1092799 | — | — | 1 | 6.21 |
| CHEMBL1090737 | — | — | 1 | 6.21 |
| CHEMBL194433 | — | — | 1 | 6.16 |
| CHEMBL1092801 | — | — | 1 | 6.08 |
| CHEMBL1092800 | — | — | 1 | 5.89 |
| CHEMBL1090061 | — | — | 1 | 5.74 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 5.60 |
| CHEMBL1077214 | — | — | 1 | 5.36 |
| CHEMBL1084701 | — | — | 1 | 5.34 |
| CHEMBL1085685 | — | — | 1 | 5.31 |
| CHEMBL1084699 | — | — | 1 | 5.28 |
| CHEMBL1086182 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077295 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1077294 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1082562 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1095037 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1077292 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL481172 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1077293 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1085684 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1083531 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1084700 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1077296 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1083526 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1087815 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1084152 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1097364 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL195453 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1086423 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL1092799 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1090737 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL194433 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1092801 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1092800 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL1090061 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL666 | FOSCARNET | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1077214 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL1084701 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL1085685 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL1084699 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL1086182 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL1095370 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1088075 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1083842 | — | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 22100.0 | nM | 4.66 |