Assay Detail
Binding
CHEMBL1116844
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Inhibition of PKA
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The development of benzimidazoles as selective rho kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.28 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1087424 | — | — | 1 | 7.70 |
| CHEMBL1087422 | — | — | 1 | 7.11 |
| CHEMBL455446 | — | — | 1 | 7.11 |
| CHEMBL1078185 | — | — | 1 | 7.09 |
| CHEMBL1087558 | — | — | 1 | 7.09 |
| CHEMBL1078113 | — | — | 1 | 6.83 |
| CHEMBL1077314 | — | — | 1 | 6.73 |
| CHEMBL454654 | — | — | 1 | 6.71 |
| CHEMBL1079212 | — | — | 1 | 6.63 |
| CHEMBL452734 | — | — | 1 | 6.60 |
| CHEMBL1077200 | — | — | 1 | 6.57 |
| CHEMBL1086921 | — | — | 1 | 6.52 |
| CHEMBL1077341 | — | — | 1 | 6.51 |
| CHEMBL1081325 | — | — | 1 | 6.51 |
| CHEMBL1099031 | — | — | 1 | 6.48 |
| CHEMBL1089378 | — | — | 1 | 6.45 |
| CHEMBL1099030 | — | — | 1 | 6.43 |
| CHEMBL1081503 | — | — | 1 | 6.36 |
| CHEMBL1098692 | — | — | 1 | 6.36 |
| CHEMBL454638 | — | — | 1 | 6.31 |
| CHEMBL1087920 | — | — | 1 | 6.30 |
| CHEMBL1081324 | — | — | 1 | 6.29 |
| CHEMBL1086791 | — | — | 1 | 6.16 |
| CHEMBL1088465 | — | — | 1 | 6.16 |
| CHEMBL1082234 | — | — | 1 | 6.15 |
| CHEMBL1088466 | — | — | 1 | 6.09 |
| CHEMBL1080402 | — | — | 1 | 6.07 |
| CHEMBL1088328 | — | — | 1 | 6.04 |
| CHEMBL1079338 | — | — | 1 | 6.00 |
| CHEMBL1092500 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1087424 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1087422 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL455446 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1078185 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1087558 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1078113 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL1077314 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL454654 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1079212 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL452734 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL1077200 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL1086921 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL1077341 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1081325 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1099031 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL1089378 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL1099030 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1081503 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL1098692 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL454638 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL1087920 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL1081324 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL1086791 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1088465 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL1082234 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL1088466 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL1080402 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1088328 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL1079338 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1092500 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL1091080 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL1088733 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1087423 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1091819 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL1092501 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL1092154 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL1078112 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL1079515 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL1079339 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL1094052 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1092795 | — | IC50 | > | 20000.0 | nM | - |