Assay Detail
Binding
CHEMBL1117043
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Inhibition of PI3K assessed as PIP3 level after 20 mins by HTRF assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.51 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.19 |
| CHEMBL1089219 | — | — | 1 | 7.62 |
| CHEMBL1088970 | — | — | 1 | 7.06 |
| CHEMBL1088919 | — | — | 1 | 6.91 |
| CHEMBL1092653 | — | — | 1 | 6.85 |
| CHEMBL1088974 | — | — | 1 | 6.82 |
| CHEMBL1092642 | — | — | 1 | 6.17 |
| CHEMBL1088973 | — | — | 1 | 6.05 |
| CHEMBL1088971 | — | — | 1 | 5.74 |
| CHEMBL1092909 | — | — | 1 | 5.67 |
| CHEMBL1092908 | — | — | 1 | 5.57 |
| CHEMBL1088972 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL1089219 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1088970 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1088919 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL1092653 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1088974 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1092642 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1088973 | — | IC50 | = | 899.0 | nM | 6.05 |
| CHEMBL1088971 | — | IC50 | = | 1819.0 | nM | 5.74 |
| CHEMBL1092909 | — | IC50 | = | 2125.0 | nM | 5.67 |
| CHEMBL1092908 | — | IC50 | = | 2692.0 | nM | 5.57 |
| CHEMBL1088972 | — | IC50 | = | 3438.0 | nM | 5.46 |