Assay Detail
Functional
CHEMBL1117501
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Inhibition of HCV con1 Cdelta55 NS5B polymerase P156S mutant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis C virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.65 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078092 | — | — | 1 | 7.40 |
| CHEMBL1079699 | — | — | 1 | 7.16 |
| CHEMBL175882 | — | — | 1 | 6.77 |
| CHEMBL366051 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078092 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1079699 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL175882 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL366051 | — | IC50 | = | 5600.0 | nM | 5.25 |