Assay Detail
Functional
CHEMBL1118249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influx
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL1075310) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.40 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 6.40 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 6.30 |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 6.10 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 5.42 |
| CHEMBL105672 | — | — | 1 | 4.68 |
| CHEMBL1082832 | — | — | 1 | 4.49 |
| CHEMBL283013 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1484 | NICARDIPINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1428 | NIMODIPINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL475534 | NITRENDIPINE | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL105672 | — | EC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL1082832 | — | EC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL283013 | — | EC50 | = | 41500.0 | nM | 4.38 |